Effect of BOL on the LSD-induced alteration of flicker discrimination in the rat.

-Rats were trained on a multiple schedule of poskive reinforcement. A stimulus light source flickering at 100 eye!e/see provided the discriminative stimulus (Sa). Under the Sa cvndidon, reir, forcemer_t was contingent upon an FRI0 _chedule. Tke same light source flickering at 30 cycle/see constituted the S_ condition. Brom-lysergic acid diethyb amide (BOL), at doses of 1 and 3/_mol/kg had no effect on discriminative ability, where_s, 10/_mol/kg BOL significantly decreased it. A dose of 0.2/_mol/kg lysergic acid diethylamide (LSD), which by itseff elevated discriminative ability, was shown not to be effected by co-adxrinistration of the three doses of BOLL. "]-'he results indicate that BOL lacks L_,D-iike effects in this test system and the LSD congener is incaFa01e of antagonizing the LSD-indueed alteration of discrimination when coadministered.